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MMP activity can be specifically inhibited by tissueinhibitors of metalloproteinases (TIMPs). ACI-24 is designed to stimu-late the patient’s immune system to produce beta-sheetconformation-specific antibodies that prevent plaquedeposition or enhance clearance of plaques (Muhs et al.,2007). If the nitro-gen in inspired air (composed of 78 % N 2 and22 % O 2) is replaced with helium—which isseven times less dense—a mixture (78 % He and22 % O 2) is obtained which is three times lessdense than normal air

If the nitro-gen in inspired air (composed of 78 % N 2 and22 % O 2) is replaced with helium—which isseven times less dense—a mixture (78 % He and22 % O 2) is obtained which is three times lessdense than normal air. The primary human lymphocyte assay is describedin more detail in the section describing human biomonitor-ing.

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Asthe patient’s exhalation of carbon dioxideincreases (i.e., increased VCO2), the level ofcarbon dioxide in the blood must decrease (i.e.,decreased PaCO2).
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